Idiopathic Sialadenosis-Salivary Gland Clinic Columbia University

Paul Ganjian DDS., Luis Mandel DDS. Journal of William Jarvie Society enlargement of the salivary glands with no known or determined contributing factors differential diagnosis includes tumors such as Warthin’s tumor,masseteric hypertrophy, Sjorgens syndrome,HIV infection,lymphoma,mumps and sarcoid.

P. Ganjian*, L. Mandel (Salivary Gland Clinic, Columbia Presbyterian Medical Center) Idiopathic sialadenosis as the name may suggest is the enlargement of the salivary glands with no known or determined contributing factors. This disease process is manifested by a non-inflammatory, non-neoplastic and generally bilateral asymptomatic hypertrophy of the salivary glands, particularly the parotid gland.

Paul_Ganjian_DDS..JPGhere is no sex predilection or association of the swelling due to eating. One common factor associated with most of these patients seems to be a peripheral sympathetic neuropathy (PSN).

The patient selection process for this study was made on the basis of exclusion of every contributing factor associated with sialadenosis which include: medications (sympathomimetic agents, antihypertensive agents, Thiocyanate and thiouracil), endocrine disorders (Diabetes mellitus, diabetes insipidus, acromegaly, hypothyroidism, myxedema, testicular or ovarian atrophy, pregnancy and lactation), Metabolic (Alcoholism, Cirrhosis, avitaminosis A, kwashiorkor, mang, beriberi and pellagra), Neurogenic (Anorexia Nervosa and bulimia), Gastrointestinal absorption disorders (celiac disease, bacillary dysentery, carcinoma of the esophagus, chagas disease, ancylostomiasis and pancreatitis) and lead, mercury or starch poisoning.

The differential diagnosis for idiopathic sialadenosis includes tumors such as Warthin’s tumor, masseteric hypertrophy, Sjorgens syndrome, HIV infection, lymphoma, mumps and sarcoid. With the extensive workups (sialography, CT scans, MRI, ultra sound, complete blood counts, blood chemistry, biopsies, etc.) for most of the patients included in this study we may be able to recognize yet another contributing factor to this benign disease entity.

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